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KMID : 0376219830200030549
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Chonnam Medical Journal
1983 Volume.20 No. 3 p.549 ~ p.559
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An Experimental Study on the Obstructive Lesion of the Submandibular Glands in Rats
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Abstract
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Sequential changes of the submandibular glands after duct obstruction in rats were observed light and electron microscopically and correlated to the expected regenerative capacity. The histological findings of the glands, 3 days and 1, 2, 3, and 5 weeks after duct ligation, could be divided arbitrarily into 3 overlapping and interrelated phases.
During the first phase (3 days) the major changes were destructive process of the acinar cells and stromal infiltration of the inflammatory cells. A few primitive epithelial nests were noted occasionally.
The second phase (1 and 2 weeks) was characterized by proliferation of the primitive epithelial cells and their differentiation to the terminal tubule cells and proacinar cells. The proliferating and differentiating epithelial cells in a nest were surrounded. by a common basal lamina and connected to one another by desmosomes, meaning that they were from the same cell line.
During the third phase (3 and 5 weeks) the primitive epithelial cells showed a regressive change: though acinar cells were newly formed in the epithelial nests or near the nests. The acinar cells showed a regressive change 5 weeks after duct ligation. Fibroblasts were progressively increased in number during the process.
From this results, the regenerative response of the submandibular glands after duct restoration was expected to be good but delayed in the first phase, good in the second phase, and fair in the third phase.
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